Network of co-mutations in Ebola virus genome predicts the disease lethality

摘要：

Dear Editor,Zaire ebolavirus (EBOV) is one of the most lethal human viruses with observed high case fatality rate (CFR) of up to 90％.The elucidation of how the genetic changes of EBOV link to its lethality will not only help us to rapidly assess the severity of the current and future EBOV outbreaks but also facilitate a deep understanding of the virus evolution.The EBOV together with the other four strains of ebolaviruses belongs to the Filoviridae RNA virus family ”1” and was first identified in 1976 in the Ebola river region of Zaire (now Democratic Republic of Congo) in the Central Africa ”2”.

所属期刊栏目：25

资助基金：This study was supported by the National Basic Research Program of China 2015CB910501,the Major National Earmark Project for Infectious Diseases 2014ZX10004002-001,and the Key Research Program of the Chinese Academy of Sciences KJZD-EW-L09-1-2 to T J,and by the National Major Scientific and Technological Special Project for ”Significant New Drugs Development” 2015ZX09102023 to GC.

在线出版日期：2015-07-10（万方平台首次上网日期，不代表论文的发表时间）

页码：753-756