TREM2 enables amyloid β clearance by microglia
In a recent paper published in Cell,Wang et al.report that deficiency of triggering receptor expressed on myeloid cells 2 (TREM2) augments amyloid β accumulation and neuronal loss in a mouse model of Alzheimer”s disease.TREM2 acts as a signaling receptor involved in innate immunity for the natural clearance of this toxic protein by microglia.
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2015-06-10(万方平台首次上网日期,不代表论文的发表时间)
535-536