Structural insights into Rhino-mediated germline piRNA cluster formation
Dear Editor,The piRNA pathway silences transposons in animal gonads.Animals lacking piRNA pathway components often show transposon activation in the germline and compromised fertility ”1”.In Drosophila germ cells,piRNA precursors are transcribed from heterochromatic piRNA cluster regions,and then transported into nuage/mitochondria to be processed into mature piRNAs that are loaded into PIWI clade Argonautes ”1”.Guided by piRNAs,PIWI proteins silence transposons at either transcriptional or post-transcriptional level ”2”.
25
This work was supported by grants from the Ministry of Science and Technology of China 2011CB966304,2012CB910502,the National Natural Science Foundation of China 31270774,and the Strategic Priority Research Program XDB08010202.
2015-05-19(万方平台首次上网日期,不代表论文的发表时间)
525-528