A novel chemopreventive strategy based on therapeutic microRNAs produced in plants
引用
分享
分享到微信朋友圈
打开微信,点击底部的“发现”,使用 “扫一扫” 即可将网页分享到我的朋友圈
Dear Editor,MicroRNAs (miRNAs) are small non-coding RNAs that play a critical role in regulation of gene expression in nearly all eukaryotic organisms,including mammals.In humans,an estimated 60% of all protein-coding genes are targeted by miRNAs,affecting virtually every physiological process in the body ”1”.In addition,a diverse array of human diseases is associated with dysregulation of miRNAs ”2”.In many forms of cancer,for example,certain miRNAs,termed tumor suppressor miRNAs,are downregulated in diseased cells.Restoration of the downregulated tumor suppressor miRNA has been shown to block one or more steps in oncogenesis in animal models and cell culture systems.Thus,the therapeutic potential of tumor suppressor miRNAs has been experimentally confirmed and is now widely recognized.However,systemic delivery of such therapeutic small RNAs in humans is challenging and numerous delivery options are currently under investigation.
25
This work was supported by a pilot project grant from the University of South Carolina Center for Colon Cancer Research NIH 5P30 GM103336-02,an ASPIRE grant from the Office of the Vice President for Research at the University of South Carolina,NIH 1R03CA181895-01A1,and NSF IOS-1029803 to VV,NIH 5R01CA154731-04 to MMP,5P30 GM103336-02 to the Mouse Experimentation Core Facility of the USC Center for Colon Cancer Research,and NIH 5R01CA151304 to LJH.