A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics

摘要：

Dear Editor,PINK1 and Parkin have been implicated in mitochondrial quality control,mitochondrial fusion/fission dynamics and axonal mitochondrial mobility in neurons ”l,2”.The PINK1-Parkin pathway is very dynamic and the biological responses mediated by the PINK1-Parkin pathway differ spatially and kinetically in different cell types ”2”.Therefore,tools to dynamically probe the function of the PINK1-Parkin pathway are highly desirable.

所属期刊栏目：25

资助基金：This work was supported by grants from the Butcher Award,Cancer League of Colorado,and National Institutes of Health CA107098 to XL and R01NS041779 to JS.EB was supported by a predoctoral training grant from NIGMS T32GM08759.The ImageXpress was supported by an NCRR grant S10 RR026680 from NIH.

在线出版日期：2015-04-17（万方平台首次上网日期，不代表论文的发表时间）

页码：394-397