Regenerative medicine: targeted genome editing in vivo
The CRISPR/Cas system has proven to be a powerful gene editing tool both in vitro and in vivo.A recent flurry of studies of in vivo gene editing using the CRISPR/Cas system bring bright prospects in creating animal models and targeted gene therapy of human genetic diseases.Animal models are invaluable in studying the mechanisms underlying human genetic disorders.However,our current knowledge of genetic diseases is limited by the time-consuming procedure of creating animal models via conventional transgenesis or gene targeting in embryonic stem cells.
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2015-04-17(万方平台首次上网日期,不代表论文的发表时间)
271-272