Adenosine activates thermogenic adipocytes
Brown or beige fat activation can cause potent anti-obesity and antidiabetic effects.In a study recently published in Nature,Gnad et al.show that adenosine is a novel activator of brown and beige fat that acts through the A2A receptor.Brown fat is a thermogenic type of adipose tissue containing abundant mitochondria and multilocular lipid droplets,and is uniquely suited and required for cold tolerance and body weight control ”1”.Upon brown fat activation,intracellular cyclic AMP (cAMP) levels rise rapidly,leading to lipolysis and upregulation of uncoupling protein 1 (UCP1)which initiates uncoupling ofmitochondrial respiration and heat generation ”2,3”.Additionally,beige or brite fat is a form of white fat that can be ”browned” and induced to engage in respiratory uncoupling similady as brown fat.
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2015-03-18(万方平台首次上网日期,不代表论文的发表时间)
155-156