WildCARDs: Inflammatory caspases directly detect LPS
Inflammasomes are sensors that serve as activation platforms for caspase-1-a mechanism that set the prevailing paradigm for int ammatory caspase activation.A recent Nature paper by Shiet al.upends this paradigm by describing an unprecedented model for caspase activation whereby caspase-4,-5,and-11 directly bind their agonist,cytosolic LPS,triggering auto-activation and subsequent pyroptotic cell death.
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2015-03-18(万方平台首次上网日期,不代表论文的发表时间)
149-150