Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation
Dear Editor,In mammalian species,the window of implantation is defined as a limited period when implantation-competent blastocyst can interact with the receptive endometrium ”1”.Besides the acquisition of blastocyst competency and uterine receptivity,initiation of embryo implantation also involves a timely reabsorption of intrauterine fluids,which facilitates the apposition of embryo with the uterine lining ”2”.These processes are coordinated by preimplantation ovarian estrogen (E2) and progesterone (P4):a small E2 surge imposed on a P4-primed environment initiates implantation ”1”,where the level of E2 and ratio of P4/E2 must be kept within an optimal range ”3,4”.
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This work was supported by the National Basic Research Program of China 2011CB944400,2011CB710905,2012CB944702 and 2015CB943000,the Strategic Priority Research Program of the Chinese Academy of Sciences XDA04020202-20 and XDA04020419 and the National Natural Science Foundation of China 31200879 and 31300957.
2015-02-06（万方平台首次上网日期，不代表论文的发表时间）
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