EGF promotes mammalian cell growth by suppressing cellular senescence
Dear Editor,Cellular senescence is a state of irreversible proliferative arrest that is believed to be an important determinant of both cancer development and organismal aging ”1”.Although numerous molecules have been found to promote senescence,little is known about the nature of anti-senescent factors under physiological conditions.To identify factors that may control the cellular senescent process,we cultured human mammary epithelial (HME) or human bronchial epithelial (HBE) cells in either complete growth medium,or medium formulated to lack individual hormones,growth factors,and other supplements commonly used in primary cell culture.
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This work was supported by National Institutes of Health CA154586 to XFW and CA059365 to PBA.
2015-02-06(万方平台首次上网日期,不代表论文的发表时间)
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