Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine

摘要：

Dear Editor,N6-methyladenosine (m6A) has been demonstrated to be ubiquitous in several types of eukaryotic RNAs,including messenger RNA (mRNA),transfer RNA (tRNA),ribosomal RNA (rRNA),long non-coding RNA (lncRNA),and small nuclear RNA (snRNA) ”1”.The recent discoveries of RNA m6A methyltransferase complex METTL3/METTL14/WTAP and demethylases FTO and ALKBH5 prove the reversibility of m6A modification ”2-6”.

所属期刊栏目：24

资助基金：This work was supported by grants from the National Basic Research Program of China 2011CB965300,the National Science & Technology Major Project ”Key New Drug Creation and Manufacturing Program” of China 2014ZX09507-002,the National Natural Science Foundation of China U1432242,91419301,31270779 and 31030019,the Basic Research Project of Shanghai Science and Technology Commission 12JC1402700,and the ”Shu Guang” project 11SG06 supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation.

在线出版日期：2015-01-07（万方平台首次上网日期，不代表论文的发表时间）

页码：1493-1496