Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition

摘要：

Dear Editor,Recent discoveries suggest that N6-methyladenosine (m6A) modification,a prevalent internal modification in eukaryotic RNA,is an essential RNA regulatory mechanism.This modification is post-transcriptionally installed by m6A methyltransferases (METTL3-METTL14-WTAP complex) ”1-4” and oxidatively removed by m6A demethylases (FTO and ALKBH5) ”5,6”.These ‘writer” and ‘eraser” enzymes are required for embryo development,energy homeostasis and fertility,suggesting fundamental regulatory roles ofm6A ”1,2,5”.

所属期刊栏目：24

资助基金：This work was financially supported by the National Basic Research Program of China 973 Program;2011CB966302,2012CB917201 and 2011CB911104,the National Natural Science Foundation of China 31170693 and 31330018,the Chinese Academy of Sciences KJZD-EW-L05,the Strategic Priority Research Program of the Chinese Academy of Sciences XDB08010101 and XDB08030302 and China Postdoctoral Science Foundation 2013M540519.

在线出版日期：2015-01-07（万方平台首次上网日期，不代表论文的发表时间）

页码：1490-1492