Crystal structure of the novel di-nucleotide cyclase from Vibrio cholerae (DncV) responsible for synthesizing a hybrid cyclic GMP-AMP

摘要：

Dear Editor,Through production of cyclic di-nucleotides as second messengers,di-nucleotide cyclases in bacteria and more recently in mammalian cells have been found to play important roles in modulating a wide range of cellular processes ”1”.During infection of V ibrio cholerae (V.cholerae),di-nucleotide cyclase Vibrio (DncV) is required for efficient intestinal colonization by V.cholerae and downregulates hyperinfectivity-associated V.cholerae chemotaxis through generation of a regulatory molecule cyclic GMP-AMP (cGAMP) ”2”.

所属期刊栏目：24

资助基金：This work was supported by the National Basic Research Program of China 973Program; 2013CB911103 and 2012CB518904,and the National Natural Science Foundation of China 81322023,31170678,31170158,31370733 and 31000332.

在线出版日期：2014-10-31（万方平台首次上网日期，不代表论文的发表时间）

页码：1270-1273