Osteogenic fate of hypertrophic chondrocytes

摘要：

Dear Editor,Endochondral bone formation is largely dependent on cartilage lineage cells.The chondrocytes in growth plates continuously undergo a sequential process from proliferation to terminal hypertrophic differentiation ”1”.Once differentiated,hypertrophic chondrocytes elicit multiple functions such as determining bone length,inducing osteogenesis as well as directing bone mineralization,and eventually disappear at the chondro-osseous junction.

所属期刊栏目：24

资助基金：This work was supported by the Chinese National Key Program on Basic Research 2012CB945103,2012CB966904,2011CB504202,and National Natural Science Foundation of China 31030040,81241062,31171249,81272702.We thank Xizhi Guo for ROSA26EYFP reporter mice and Peng Li for perilipin antibody.

在线出版日期：2014-10-31（万方平台首次上网日期，不代表论文的发表时间）

页码：1266-1269