The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells

摘要：

Dear Editor,In eukaryotes,increased protein folding demand at the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) ”1”,which plays a pivotal role in control of cellular functions and survival under ER stress ”2”.Chronic ER stress is thought to contribute to the pathogenic progression of diabetes ”3,4”.Inositol-requiring enzyme 1 (IRE 1),an ER-resident transmembrane Ser/Thr protein kinase and endoribonuclease,is the most conserved ER stress sensor that mediates a key branch of the UPR ”1”.

所属期刊栏目：24

资助基金：This work was supported by grants from the Ministry of Science and Technology of China 973 Program; 2012CB524900 and 2011CB910900,the National Natural Science Foundation of China 31230036,81321062 and 91213306 and the Chinese Academy of Sciences The Knowledge Innovation Program No.KSCX2-EW-R-09 to YL; the National Natural Science Foundation of China 81170814 and the Ministry of Education of China for PhD program 20100131110037 to XW; and the National Natural Science Foundation of China 81200562 to LY.

在线出版日期：2014-10-08（万方平台首次上网日期，不代表论文的发表时间）

页码：1137-1140