”PEST control”: regulation of molecular barcodes by tyrosine phosphatases
The emerging concept of ”molecular barcodes” refers to the dynamic combination of post-translational modifications,often of different nature (e.g.,phosphorylation and ubiquitination) that gives rise to multiple forms of a protein which can relay distinct signals throughout a cell.In a recent Cell Research paper by Wang et al.,the authors report that a PEST domain-containing tyrosine phosphatase,PTPN18,is able to regulate both phosphorylation and ubiquitination of the HER2 oncogene,barcoding HER2 for increased proteasomal degradation rather than for intracellular trafficking.
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2014-10-08(万方平台首次上网日期,不代表论文的发表时间)
1027-1028