Lis1 is required for the expansion of hematopoietic stem cells in the fetal liver
Dear Editor,Hematopoietic stem cells (HSCs) are responsible for the lifelong production of all blood cells ”1”.Like many other tissues and organs,the hematopoietic system develops during embryogenesis ”2”.One of the challenges of this developing process is to generate a functional HSC pool,which is a prerequisite for seeding bone marrow and thereafter lifelong hematopoiesis ”3”.HSC expansion is critical for the establishment of such HSC pool ”2”.To accomplish the expansion,the fetal liver HSCs (FL-HSCs) are continuously undergoing symmetric cell division,which requires precise collaboration of multiple cellular processes ”2”,especially those that serve to maintain the genomic stability of the dividing HSCs.Many factors have been shown to be involved in FL-HSC expansion.Growth factors such as insulin-like growth factor 2 (IGF2) and stem cell factor (SCF) stimulate FL-HSC proliferation ”4,5”,and key transcription factors such as Gata2 and PU.1 regulate the proliferation and maintenance of fetal HSCs by regulating multiple downstream target genes ”6,7”.However,the intrinsic factors that directly regulate FL-HSC expansion remain to be investigated.
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This work was supported by the National Basic Research Program of China 973 Program; 2013CB835300 and 2012CB518700,the National Natural Science Foundation of China 81261120380 and 31270936 and Shanghai Municipal Government Grant 12XD1405800.
2014-09-10（万方平台首次上网日期，不代表论文的发表时间）
1013-1016
