The soft underbelly of tumor cells
In a recent Cellpaper,Kitambi and colleagues identify a small molecule (Vacquinol-1) that has beneficial effects on a glioblastoma multiforme mouse model by oral administration.In glioblastoma cells,Vaequinol-1 targets macropinocytosis,a cellular process that will not lead to cell death in normal cells.Current treatments for glioblastoma multiforme (GBM) include surgical resection,when possible,with concomitant radiotherapy and chemotherapy.Yet GBM remains an essentially incurable disease with median survival of about one year.Kitambi and colleagues ”1” report that a small molecule Vacquinol-1 can specifically induce human glioblastoma cell (GC) death,attenuate tumor progression and prolong survival in a GBM mouse model.Vacquinol-1 induces GC death by a catastrophic unconventional cell death pathway.
24
2014-09-10(万方平台首次上网日期,不代表论文的发表时间)
910-911