Regulating the regulator of ROS production
Balancing inflammatory reactive oxygen species (ROS) production is essential for safely eliminating pathogenic microbes.The newly described protein (N)egative Regulator of (ROS) (NRROS) dampens ROS production by restricting NOX2 availability,and thus ”cools-off” inflammation.Oxygen-based metabolism was essential for proliferation and diversification of life on Earth but imposed the need to cope with reactive oxygen species (ROS) as an unavoidable aspect of aerobic respiration.Multicellular organisms have evolved a host of mechanisms to utilize ROS to their advantage,thus employing them as mediators of cellular signaling and bactericidal agents against invading pathogens.
24
2014-09-10(万方平台首次上网日期,不代表论文的发表时间)
908-909