Targeting Th17 cells in immune diseases

摘要：

Last decade has seen quick developments in the understanding of a new type of T lymphocytes,Th17 cells.This information is benefiting the understanding and treatment of a variety of inflammatory diseases,as suggested by a recent paper in Immunity.After activation by antigen-presenting cells (APC),naive,antigen-specific CD4+ T cells differentiate into effector T cells.More than two decades ago,Coffman and Mosman first discovered the heterogeneity of effector T cells,which were then named as Th1 or Th2 cells.Th1 and Th2 cells are differentially induced and regulate immunity against intracellular and extracellular pathogens,respectively,as well as immunopathologies such as autoimmunity and allergy.The Th1/Th2 dichotomy has dominated the field of immune regulation until five years ago when IL-17-expressing T cells were proposed to be a third lineage of helper T cells.

所属期刊栏目：24

在线出版日期：2014-09-10（万方平台首次上网日期，不代表论文的发表时间）

页码：901-903