Akt: a new activation mechanism
Akt phosphorylation at S473 and T308 has been believed to be the prerequisites for its activation for years.Now,new phosphorylation event on Akt is identified and can trigger Akt activation and lead to its downstream oncogenic events.Protein Kinase B (PKB),more commonly referred to as Akt,is a serine/threonine-specific protein kinase.It is well established as a critical signaling node that regulates a myriad of cellular functions including proliferation,survival,apoptosis and metabolism,which are also processes important for tumorigenesis ”1”.Indeed,the roles of Akt in cancer have been extensively scrutinized over the years and documented in many studies.However,more studies are still emerging to further increase our knowledge of this complex master regulator.In a recent paper published in Nature,Liu et al.”2” have identified a new phosphorylation event on the Akt extreme carboxyl (C)-terminus,specifically on residues S477 and T479,which activates Akt and subsequent downstream oncogenic cellular functions.
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2014-08-22(万方平台首次上网日期,不代表论文的发表时间)
785-786