Identifying specific receptors for cargo-mediated autophagy
Macroautophagy has been implicated in numerous diseases,yet our understanding of the proteins responsible for the turnover of specific cargo by autophagy is limited.In a recent paper published in Nature,Mancias et al.used quantitative proteomics to identify a cohort of autophagosomeenriched proteins,one of which,nuclear receptor coactivator 4 (NCOA4)was shown to be required for the selective delivery of ferritin to the lysosome,ultimately regulating intracellular iron by autophagic turnover of ferritin,or ferritinophagy.
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2014-08-22(万方平台首次上网日期,不代表论文的发表时间)
783-784