Keeping 53BP1 out of focus in mitosis

摘要：

A recent study published in Science reveals the mechanism and biological importance of DNA damage response abrogation in mitotic cells.For many years,much research has focused on understanding how cells maintain genome integrity despite DNA being constantly challenged by factors of both endogenous and exogenous nature.DNA double-strand breaks (DSBs) are the most deleterious DNA lesions,and if left unrepaired or repaired incorrectly,a single DSB can trigger genome instability or even cell death ”1”.Therefore,any DSB has to be recognized and repaired by processes encompassed within the DNA damage response (DDR).Notably,while the ends of mammalian linear chromosomes naturally resemble DSBs,their structure and association with the so-called ”Shelterin” complex normally makes them invisible to the DDR ”2”.

所属期刊栏目：24

在线出版日期：2014-08-22（万方平台首次上网日期，不代表论文的发表时间）

页码：781-782