Mediator redefines itself
Mediator is a large and structurally dynamic protein complex that is globally required for eukaryotic transcription by RNA polymerase Ⅱ.In a recent paper published in Cell Research,Wang et al.report for the first time the location of distinct subunits and redefine domains in the S.cerevisiae Mediator complex.The Mediator complex is specific to eukaryotic organisms and,despite significant divergence in subunit sequence identity,several basic functions of the complex (e.g.,interaction with DNA-binding transcription factors and RNA polymerase Ⅱ (pol Ⅱ),and general requirement for genome-wide transcription) are conserved between yeast and mammals ”1”.Mediator possesses a disproportionately large number of predicted intrinsically disordered regions in the sequences of its subunits ”2”.Many of the intrinsically disordered regions have sequence signatures that suggest the presence of protein-protein binding domains although the exact nature of these putative interactions remains largely unknown.
24
2014-08-22(万方平台首次上网日期,不代表论文的发表时间)
775-776