Possible leap ahead in filovirus therapeutics
In a recent study published in Nature,Warren et al.describe the generation of a novel synthetic adenosine analogue,BCX4430,a synthetic druglike small molecule that provides protection from Ebola and Marburg virus infection in animal models.While this is not the first small molecule with in vivo efficacy against filovirus infections (as summarized in ”1”),it is the first showing efficacy in a nonhuman primate model.Clinically useful treatments for Ebola and Marburg viruses have been elusive and until now,potential post-exposure therapies have faced practical,regulatory,safety and/or cost obstacles.BCX4430 demonstrated up to 100% protection when administered as late as 48 h following infection with Marburg virus (strain Musoke) in the cynomolgus macaque model.
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2014-07-14(万方平台首次上网日期,不代表论文的发表时间)
647-648