The lock-washer: a reconciliation of the RIG-Ⅰ activation models
RIG-Ⅰ belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system.A report by Peisley et al.published in Nature provides the crystal structure of human RIG-Ⅰ revealing a tetrameric architecture of the RIG-Ⅰ 2-CARD domain bound by three K63-linked ubiquitin chains,uncovering its activation mechanism for downstream signaling.
24
2014-07-14(万方平台首次上网日期,不代表论文的发表时间)
645-646