”Lnc”-ing enhancers to MYC regulation
Long noncoding RNAs (lncRNAs)are emerging as important functional components in the establishment of long-range chromosomal interactions.In a recent paper published in Cell Research,Xiang et al.provide mechanistic insight into this phenomenon by characterizing the role of CCAT1-L,a colorectal cancer-specific IncRNA,in intra-chromosome looping between the MYC gene promoter and distal upstream enhancer elements that regulate MYC transcription.
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2014-07-14(万方平台首次上网日期,不代表论文的发表时间)
643-644