Complete decoding of TAL effectors for DNA recognition

摘要：

Dear Editor,The most striking feature of a transcription activa tor-like effector (TALE) is the presence of a central DNA-binding region composed of tandem repeats of about 34 amino acids ”1”.Two hypervariable residues at positions 12 and 13 (repeat-variable diresidues or RVDs) in each repeat bind to DNA,and this modular DNA-binding feature of TALE repeats has inspired the development of custom-designed TALE repeats for gene editing ”2,3,4,5”.The nucleotide recognition preference of the commonly used RVDs has been experimentally or computationally determined ”2,5”.

所属期刊栏目：24

在线出版日期：2014-06-12（万方平台首次上网日期，不代表论文的发表时间）

页码：628-631