Recurrent mutations at C-reactive protein gene promoter SNP position-286 in human cancers
Dear Editor,
Genetic alteration and inflammation underlie the development of cancer [1].C-reactive protein (CRP) is the most widely used nonspecific marker of inflammation [2],whose serum level has been shown to be associated with the risk and prognosis of several types of cancer [3].Accumulating evidence supports a role of CRP as a pattern recognition receptor in the innate immunity and inflammation [4];however,its exact function remains to be defined because mouse is not an appropriate animal model for CRP [5].Moreover,as a prototypical acute phase reactant,the 2-3-order fluctuation in the serum level of CRP has raised the concern that this molecule is not likely a fine modulator of inflammation [2].
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grants from the MOST2011CB910500;NSFC30930024,31222015,31270813,31170696;MOEPCSIRT:IRT1137,121108
2014-05-12(万方平台首次上网日期,不代表论文的发表时间)
共4页
505-508