Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex

摘要：

Dear Editor,
The Lsm (Sm-like) family of proteins,characterized by the Sm fold [1] and conserved among eukaryotes,plays an important role in RNA biogenesis.The Sm and Lsm complexes play an essential role in pre-mRNA splicing [2].Of the five small ribonucleoproteins (snRNPs),four (U1,U2,U4,U5) contain the Sm heptamer ring,whereas the U6 snRNP contains a specific Lsm2-8 heptamer that comprises Lsm2,Lsm3,Lsm4,Lsm5,Lsm6,Lsm7,and Lsm8 [3].Another Lsm heptameric complex,Lsm1-7,which differs from Lsm2-8 by one Lsm protein,is thought to function in mRNA decapping,a crucial step in the mRNA degradation pathway [4].

所属期刊栏目：24

资助基金：the National Natural Science Foundation of China 31130002 and 31021002.The atomic coordinates have been deposited in the Protein Data Bank with the accession code 4M75

在线出版日期：2014-05-12（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：497-500