Generation of transgenic golden Syrian hamsters

摘要：

Dear Editor,
Golden Syrian hamsters are small rodents,but they display many features that resemble the physiology and metabolism of humans.Hamsters have been widely used in many research areas,including carcinogenesis [1],reproduction [2],virology [3],diabetes [4] and cardiovascular diseases [5].With respect to lipid and glucose metabolism,hamsters,like humans,exhibit high levels of cholesteryl ester transport protein (CETP),intestinalonly ApoB editing,low levels of hepatic low-density lipoprotein (LDL) receptor activity [6] and a high glycemic response to dietary fructose [7],all of which are not observed in other rodents such as mice and rats.Consequently,hamsters,like humans,exhibit enhanced susceptibility to atherosclerosis (AS) and diabetes [8],which led to the widespread use of hamsters in studies on AS and diabetes.

所属期刊栏目：24

资助基金：the National Basic Research Program of China2011CB503900 and 2012CB517505;the National Natural Science Foundation of China to G Liu30930037 and 81121061

在线出版日期：2014-04-21（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：380-382