Aberrant ceRNA activity drives lung cancer

摘要：

In a recent issue of Nature,Kumar et al.demonstrate that the oncogenic potential of the Hmga2 gene is largely due to the ability of its transcript to operate as a competing endogenous RNA in a protein coding-independent manner.The Hmga2 mRNA decoys the let-7 microRNA family to regulate Tgfbr3 expression and enhance TGF-β signaling,thereby promoting lung cancer progression.
MicroRNAs are a large class of small non-coding RNAs which regulate gene expression by binding to microRNA response elements (MREs) on target transcripts.It has become increasingly clear in recent years that transcripts which contain MREs for shared microRNAs can co-regulate each other by titrating microRNA availability,thus acting as natural microRNA sponges or competing endogenous RNAs (ceRNAs) [1,2].Although ceRNA activity has been attributed to both protein-coding and non-coding RNAs such as small noncoding RNAs,long non-coding RNAs,pseudogenes and circular RNAs in diverse species,little is known about the precise molecular conditions needed for optimal ceRNA crosstalk.

所属期刊栏目：24

在线出版日期：2014-04-21（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：259-260