Stereotyped distribution of midbody remnants in early C.elegans embryos requires cell death genes and is dispensable for development
Dear Editor,
The midbody is a structure formed within the intercellular bridge towards the end of cytokinesis [1].Microtubules within this bridge are then severed on one side of the midbody during abscission,thus generating a midbody remnant in one of the resulting daughter cells.Midbody remnants persist long after cell division and accumulate preferentially in stem cells,induced pluripotent stem (iPS) cells,and cancer stem cells [2-4].Upon induction of differentiation,midbody remnants are degraded by autophagy or released into the extracellular milieu in some tissue culture cells,and it has been proposed that such removal is critical for enabling a differentiation program [2-4].However,the fate of midbody remnants in a developing organism remains elusive,and whether their presence plays a role in cell fate determination in vivo is not known.
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We thank Virginie Hachet and Femando R Balestra for useful comments on the manuscript, as well as Michael Glotzer for the gifi of ZEN-4 antibodies. We also thank Olivier Burri and RomainGuiet from the Bioimaging and Optics Platform BIOP at EPFL for their help with elaboration of movies. This workSSTC_EG09_092011;grants from the National Basic Research Program2012CB945002 and 2013CB945600;the National Natural Science Foundation of China31222035, 31190063 and 31171295
2014-03-20（万方平台首次上网日期，不代表论文的发表时间）
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