How to correct chromosomal trisomy

摘要：

Global gene expression analyses show that not only chromosome 21-1inked genes but also genes on other chromosomes are disrupted in cells with trisomy 21,suggesting wide effects on the transcriptome.Because such comparisons are usually between different individuals and not between isogenic cells,a large portion of the changes observed could be due to variants unrelated to the trisomy.In fact,few specific genes have been implicated in the trisomy phenotypes,and the effects of abnormal gene dosage are not clear in different tissues.The fold-increase in expression for genes on chromosome 21 is about 1.2-1.4 and only reaches the theoretical 1.5 for a minor portion of genes in trisomic cells,suggesting that dampening effects partially correct abnormal expression levels.Basal dampening and feedback mechanisms mitigate deleterious dosage effects of aneuploidy [1,2].To achieve correct gene expression,additional feed-forward mechanisms of dosage compensation evolved,for example to regulate the X chromosome.Such mechanisms include X upregulation to increase expression from the single active X chromosome,and X inactivation to silence one X chromosome in mammalian females [1].

所属期刊栏目：23

在线出版日期：2014-01-23（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：1345-1346