Coordinated regulation of AMPK activity by multiple elements in the α-subunit

摘要：

Dear Editor,
The AMP-activated protein kinase (AMPK) is the key energy sensor in response to various stresses that decrease cellular ATP levels,including low glucose,hypoxia,ischemia and heat shock.Recently,evidence has suggested that AMPK also plays critical roles in coupling the cellular bio-energetic state to various physiological processes,such as tumor suppression,cell polarity,life span,circadian clock,gene transcription and autophagy.Thus,AMPK represents a potential drug target for metabolic disorders and cancer treatment [1,2].

所属期刊栏目：23

资助基金：the National Natural Science Foundation of China31130062;the National Key Basic Research Program of China2013CB530603;Tsinghua University20121080028

在线出版日期：2013-11-14（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：1237-1240