New hope for therapy in neurodegenerative diseases
The use of genetic screens to define cellular pathways that regulate neurodegenerative disease proteins has emerged as a powerful strategy to identify potential therapeutic targets for these disorders.Using crossspecies genetic screens,Park et al.recently identified RAS-MAPK-MSK1 as a cellular pathway that modulates levels of the polyglutamine-containing proteinATXN1 and its subsequent toxicity in SCA1.
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2013-11-14(万方平台首次上网日期,不代表论文的发表时间)
共2页
1159-1160