EGFR gets in the way of microRNA biogenesis
Recent studies suggest that microRNA (miRNA) processing is a key regulatory step in the miRNA biogenesis as well as its transcriptional control.In a paper recently published in Nature,Shen et al.revealed that epidermal growth factor receptor (EGFR) directly interacts with argonaute 2 (AGO2),a critical component of RNA-induced silencing complex (RISC),and inhibits the maturation of specific tumor suppressive miRNAs under hypoxic condition.
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2013-11-14(万方平台首次上网日期,不代表论文的发表时间)
共2页
1157-1158