Establishing brain functional laterality in adult mice through unilateral gene manipulation in the embryonic cortex
Dear editor,
Brain functional laterality appears either in individuals or in a population in vertebrates,though the degree of asymmetry varies [1,2].Behavioral asymmetry such as paw preference,a food reaching skill,is observed in individual mice to a certain degree in some strains,but not on a larger population level and not in all strains [3].The hemisphere with the larger motor cortex tends to be dominant in controlling manual skills,leading to a stronger preference of using the contralateral front paw [4,5].However,the mechanism underlying the establishment of the dominant functional areas in the left or right hemispheres is poorly understood [6,7].
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the Ellison Medical Foundation;the Hirschl/Weill-Caulier Trust;the Qatar National Research Fund;an R01-MH083680 grant from the NIH/NIMH
2013-10-23(万方平台首次上网日期,不代表论文的发表时间)
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1147-1149