Sirtuins as therapeutic targets of ALS

摘要：

Sirtuins have received a lot of attention in biological functions associated with metabolism,survival development,and most recently,neurodegeneration.The versatile role of sirtuins can be readily redirected for drug discovery studies for novel treatment in amyotrophic lateral sclerosis (ALS),as presented in this highlight,by sirtuin-mediated ketogenic responses influencing mitochondrial function.
Modulation of sirtuin activity has been shown to impact the course of several aggregate-forming neurodegenerative disorders including Alzheimer's disease (AD),Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy.Sirtuin proteins possess either mono-ribosyltransferase or deacetylase activity.Sirtuins have been linked with caloric restriction (CR) and aging by modulating energy metabolism,genomic stability and stress resistance.For example,our laboratory was the first to demonstrate that promotion of the NAD+-dependent SIRT1-mediated deacetylation,may be a mechanism by which CR influences AD-type amyloid neuropathology [1].

所属期刊栏目：23

在线出版日期：2013-10-23（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：1073-1074