Channel gating pore: a new therapeutic target
Each subunit of voltage-gated cation channels comprises a voltagesensing domain and a pore region.In a paper recently published in Cell Research,Li et al.showed that the gating charge pathway of the voltage sensor of the KCNQ2 K+ channel can accommodate small opener molecules and offer a new target to treat hyperexcitability disorders.
Voltage-gated cation channels (VGCCs) are key players of many vital functions and their genetic defects in humans can lead to severe diseases,called "channelopathies" [1].Each channel α subunit possesses two main transmembrane modules,a voltage-sensing domain (VSD) and a pore region.VSDs are membrane protein modules comprising four membrane-spanning segments (S1-S4) endowed with charged amino acids,also called gating charges [2].
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2013-10-23(万方平台首次上网日期,不代表论文的发表时间)
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1067-1068