Crystal structure and nucleotide selectivity of human IFIT5/ISG58
Dear editor,
Interferon-stimulated gene 56 (ISG56) family members,ISG56,ISG54,ISG58 and ISG60,also known as interferon-induced protein with tetratricopeptide repeats (TPR) 1 (IFIT1),IFIT2,IFIT5 and IFIT3,respectively,play crucial roles in human antiviral defense systems.Recent studies have shown that ISG56 specifically recognizes viral 5'-pppRNA [1].Using structural biology methods,we found that ISG54 possesses a right-handed helical channel in its C-terminal region,which recognizes AU-rich RNAs [2].ISG54 mutants whose nucleotidebinding sites were destroyed showed a significant loss of their antiviral activities [2].As the expression patterns of ISG56 family proteins have been reported to be cell-and inducer-specific [3],we hypothesize that different ISG56 family members likely recognize distinct substrates.
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grants to H Liang31000331;Y Liu from the Ministry of Science and Technology973 Programs 2011CB910304,2012CB910204;the National Science Foundation of China30925011,31030024 and 31021062;by two NIH research grantsR01GM078607 and R01AI069120
2013-10-16(万方平台首次上网日期,不代表论文的发表时间)
共4页
1055-1058