Regeneration potential of adult cardiac myocytes
Although adult cardiac myocytes (CMs) have very little proliferative potential,fetal CMs divide robustly.The mechanisms underlying the post-mitotic state of CMs are poorly understood;however,recently Mahmoud et al.identified a homeodomain transcription factor,Meis1,which controls postnatal CM cell cycle.
In mammals,cardiac growth during embryonic development is primarily dependent on hyperplasia (increase in cell number).Cardiac myocytes (CMs),however,lose their ability to proliferate soon after birth and heart growth switches predominantly to hypertrophy (an enlargement of cell size).
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2013-10-16(万方平台首次上网日期,不代表论文的发表时间)
共2页
978-979