Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome

摘要：

Dear Editor,
Many opportunistic fungi are devastating pathogens that cause lethal infection.Cryptococcus neoformans (C.neoformans) is such a fungus that mainly infects immunocompromised hosts such as AIDS patients as well as organ transplant recipients,and causes cryptococcosis including life-threatening meningoencephalitis [1].Cryptococcal meningitis affects about a million AIDS patients and causes 625 000 deaths in the world yearly [2].The disease also occurs in apparently immunocompetent individuals [3].However,host immune responses to C.neoformans are not well studied.

所属期刊栏目：23

资助基金：grants from 100 Talent Program of the Chinese Academy of Sciences,the National Natural Science Foundation of China91029707,31170868,812111134,31100622;Shanghai Natural Science Foundation11ZR1442600;Novo Nordisk-CAS Research Foundation,SA-SIBS Scholarship Program,Chinese Postdoctoral Science Foundation20110490752;Postdoctoral Research Foundation of Shanghai Institutes for Biological Sciences2011KIP513;as well as grants from the National Key Basic Research Program2013CB531600;National Science and Technology Major Project 2012ZX10002007-003 of China

在线出版日期：2013-08-08（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：965-968