Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin-CD34+cord blood cells
Dear Editor,
Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by the oncogenic BCR-ABL fusion gene with increased ABL tyrosine kinase (TK) activity [1].Transduction of primitive hematopoietic cells with the BCR-ABL oncoprotein creates cells that display many features of their BCR-ABL+ counterparts in CML patients.Inhibition of the TK activity of BCR-ABL by small molecule inhibitors (imatinib mesylate (IM),dasatinib and nilotinib) [2] causes impressive responses in chronic phase CML patients.Nevertheless,response failures,early relapses and the later emergence of IM-resistant disease remain significant problems for many patients.In particular,CML stem cells are insensitive to IM and other ABL inhibitors and are not eradicated by currently available agents [1,3].These findings underscore the importance of understanding the biology of CML stem/progenitor cells and their unique properties in vivo,in guiding the development of strategies to permanently cure CML.
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the National Natural Science Foundation of China81125003,30770242 and 30870943 to FZ;the National Key Scientific Research Program of China2007CB947800 and 2010CB945200;the National Basic Research Program of China2007CB511904 to SH;the State Key Scientific Project of China2008ZX08008-004 to SH;the State and Shanghai Key Academic Discipline of ChinaB204 to SH;the Science and Technology Committee of Shanghai Municipality10140900200 and 08dj1400502 to FZ;the Canadian Cancer Society Research Institute;the Cancer Research Society,the Leukemia & Lymphoma Society of Canada and the Canadian Cancer Society to X J.X Jiang is a Michael Smith Foundation for Health Research Scholar
2013-07-29（万方平台首次上网日期，不代表论文的发表时间）
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859-862
