Mouse models uncap novel roles of SSBs
Three recently published reports,including one in Cell Research,generated Ssb1 knockout mice and demonstrated critical roles of this protein in regulating skeletogenesis,telomere homeostasis and tumor suppression.
Single-stranded DNA binding proteins (SSBs) regulate numerous cellular transactions and are typified by the presence of conserved oligosaccharideoligonucleotide (OB)-fold binding domains.RPA,the canonical SSB in eukaryotes,is an essential component of DNA replication and repair.
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2013-07-29(万方平台首次上网日期,不代表论文的发表时间)
共2页
744-745