The FBW7-KLF2 axis regulates endothelial functions

摘要：

FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins,and induces endothelial differentiation by modulating the NF1/RAS axis.A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.
The SCFFBW7 E3 ubiquitin ligase,consisting of SKP1 adaptor protein,CULl scaffold protein,RBX1 or RBX2 (also known as SAG) RING protein,and FBW7 substrate recognizing protein,regulates various cellular processes,including cell proliferation and survival,endothelial differentiation,and tumorigenesis by promoting a timely ubiquitylation and degradation of its substrates [1] (Figure 1).

所属期刊栏目：23

在线出版日期：2013-07-29（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：741-743