Engaging the p53 metabolic brake drives senescence
Emerging evidence suggests that the ability of p53 to regulate metabolism is important for its tumor suppressor activity.A recent study published in Nature reveals a novel connection between p53 and metabolism:p53 transcriptionally represses the expression of malic enzymes and associated NADPH production,which in turn triggers a positive feedback loop resulting in sustained p53 activation,cellular senescence,and tumor suppression.
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2013-07-29(万方平台首次上网日期,不代表论文的发表时间)
共2页
739-740