Viral counterattack against the host innate immune system
Paramyxoviruses evade antiviral immune response using a small nonstructural protein,V,which binds to the host dsRNA sensor MDA5 and prevents it from activating the interferon signaling pathway.A recent crystal structure of the V protein in complex with MDA5,published in Science,revealed that V disrupts the structure of MDA5 and is integrated into the MDA5 protein fold,providing an intriguing new example of viral mimicry as a countermeasure against the host immune system.
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2013-07-29(万方平台首次上网日期,不代表论文的发表时间)
共2页
735-736