Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis

摘要：

Dear Editor,
Tuberculosis (TB),an infectious disease caused by the bacillus Mycobacterium tuberculosis,leads to substantial mortality worldwide [1].The emergence of multidrugresistant (MDR) and extensively drug-resistant (XDR) strains of M.tuberculosis has challenged conventional anti-TB therapy and threatens global disease control of TB [2,3].The development of new anti-TB drugs is urgently required [4].β-lactams are effective antibiotics widely used to treat bacterial infections;however,so far no effective anti-TB antibiotics have emerged from this class of drugs.Previous studies have indicated that an important reason for the lack of effective β-lactam anti-TB antibiotics is the presence of a chromosomallyencoded class A (Ambler) β-lactamase,BlaC,in M.tuberculosis [5].

所属期刊栏目：23

资助基金：This work was funded by National Basic Research Program of China973 Program,2011CB910300,2011CB911103 and 2013CB911500;the Chinese Academy of SciencesKSCX2-EW-J-3

在线出版日期：2013-07-01（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：728-731