Proteasome-independent p53 degradation
The intracellular levels of the p53tumor suppressor protein are regulated through various pathways and involve numerous regulatory components.A recent study published in CellResearch identifies a proteasomeindependent pathway of p53 protein degradation in the nucleolus that is dependent on Def and Calpain3.
The p53 tumor suppressor protein is a central player in the cellular response to stress.In response to diverse stress signals including DNA damage,nutrient deprivation and oncogene activation,p53 protein becomes activated and functions as a sequence-specific DNA-binding transcription factor to regulate the expression of both protein-coding and-noncoding genes that collectively result in cell cycle arrest,senescence or apoptosis.
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2013-07-01(万方平台首次上网日期,不代表论文的发表时间)
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